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pentobarbital will reduce the level or effect of pitolisant by impacting hepatic/intestinal enzyme CYP3A4 metabolism. Modify Therapy/Watch Intently. Pitolisant exposure is lessened by fifty% if coadministered with potent CYP3A4 inducers.pentobarbital will minimize the extent or result of roflumilast by affecting hepatic/intestinal enzyme CYP3A4 met